One-pot Multicomponent Syntheses of Functional Chromophores –

Synthetic Efficiency Meets Functionality Design

Thomas J. J. Müller / Heinrich-Heine-University Düsseldorf, Germany

Introduction

One-pot processes have considerably enhanced diversity-oriented syntheses in the past decades and have become an enabling tool for providing myriads of substance libraries, in particular, in pharmaceutical high-throughput screening and lead finding. Over the past two decades, we have paved the way of multicomponent reactions (MCR) as a synthetic concept to access functional p-electron systems, such as chromophores, fluorophores, and electrophores, by scaffold and chromophore approaches. Transition metal catalyzed couplings are excellent entries to alkynones, which can be transformed by multi-component and domino processes to various classes of functional fluorescent chromophores in a one-pot fashion (chromophore concept). In the lecture the general concept is introduced and illustrated by the development of ethynyl quinoxalines and aroyl-S,N-ketene acetals, novel classes of polar solid-state and aggregation-induced emissive dyes.

References

L. Biesen, T. J. J. Müller, Chem. Eur. J. 2023, 29, e202302067.
L. Brandner, T. J. J. Müller, Front. Chem. 2023, 11, 1124209.
L. Biesen, T. J. J. Müller, Adv. Synth. Catal. 2021, 363, 980.

Thomas J. J. Müller

studied chemistry (1984-1989) at the University of München (LMU) (diploma 1989; Ph.D. 1992). After a post-doctoral stay at Stanford University (1993/1994), he developed his independent research at Technical University Darmstadt and LMU (1994-1999; habilitation 2000). After a professorship at the University of Heidelberg (2002-2006) he is a chaired full professor at the University of Düsseldorf since 2006, and since 2019 the spokesman of the Research Training Group 2482 funded by the German Science Foundation (DFG). Since 2021 he is a foreign member of the National Academy of Sciences of Ukraine. His research interests encompass synthetic and physical-organic chemistry of functional chromophores, and the design of novel one-pot reactions, documented in more than 300 publications.