Fluorinated organic azides: From chemical curiosities to versatile building blocks

Petr Beier / Institute of Organic Chemistry and Biochemistry, Academy of Sciences, Prague, Czech Republic

September 15, 2022, 2 - 3 pm CEST

Online live talk

Introduction

Organic azides are widely used and versatile building blocks. Their fluorinated derivatives however have been very rare and their stability and reactivity has not been studied. In recent years we have described the synthesis of a library of new organic fluorinated azides from azidotrifluoromethane to more complex ones, demonstrated their superior stability compared to nonfluorinated azides and studied their unique reactivity in cycloadditions, annulations, protonation, or nitrene formation. Thus, fluorinated azides are no longer chemical curiosities but useful reagents in the synthesis of novel nitrogen heterocycles, enamides, imidoyl halides, ketenimines, and other structures with potential applications in life science and material chemistry.

Petr Beier

Petr Beier obtained his M.Sc. in Organic Chemistry at the University of Pardubice, Czech Republic in 2001 and his Ph.D. in Organic Chemistry at the University of St Andrews, United Kingdom in 2004. After his postdoctoral studies at the University of Southern California, Los Angeles, USA (2005-2006) he started his independent career as a research group leader at the Institute of Organic Chemistry and Biochemistry, Academy of Sciences, Prague, Czech Republic. He received the Alfred Bader Prize for Organic Chemistry in 2013 and the Royal Chemical Society Fluorine Prize in 2017. In his research, he focuses on the chemistry of main group elements, methodology development, reactive intermediates, asymmetric synthesis, investigation of reaction mechanism and organometallic chemistry.

Petr Beier is the author of nine articles in the Beilstein Journal of Organic Chemistry.