Cryo-EM in Enzymology I:
Structural basis of pH dependence, ligand specificity, and temperature effect

Ming-Daw Tsai / Academia Sinica, Taipei, Taiwan

April 14, 2021, 8 - 9 am (CEST) & 5 - 6 pm (CEST)

Online live talk

Ming-Daw Tsai

Professor Ming-Daw Tsai received B.S. degree from National Taiwan University (1972) and Ph.D. from Purdue University (1978), and served in the faculty of the Department of Chemistry and Biochemistry, The Ohio State University in 1981-2006. Subsequently he moved to the Institute of Biological Chemistry of Academia Sinica, Taiwan. His research interests include mechanistic enzymology of phosphoryl transfer enzymes including DNA polymerases, kinases and phospholipases, and structure-function relationship of proteins in DNA damage response and cancer signaling, including ankyrin repeat proteins and FHA domain proteins. A recent focus is on the roles of TIFA in cancer and immunity. He probes mechanistic problems by applying emerging methodologies in structural biology, including NMR, X-ray crystallography, MS, and recently cryo-EM, leading to close to 300 publications. He was elected to Fellow, American Association for the Advancement of Science (AAAS, 1992), Academician, Academia Sinica (2012), and Fellow, The World Academy of Science (TWAS, 2014).