The Beilstein Nanotechnology Symposium “Translational Trends in Nanomedicine” took place at a beautiful “hunters castle” surrounded by forests with an ecstatic view of the Rhein valley. The highlight of the conference was its small size, enabling fruitful scientific discussions and one-to-one interactions in a stimulating environment. The speakers collectively provided an excellent overview on the use of nanomaterials for advancements in the field of drug delivery, bio-imaging, anti-viral therapeutics, and regenerative medicine. The talks were broadly categorized into three topics: (i) the use of nanoparticles for targeted delivery and imaging, (ii) hybrid materials for nanomedicine and regenerative medicine, and (iii) peptide assemblies and their mimicries as biomaterials. The conference was structured such that the use of nanomaterials for in vivo applications to their supramolecular assemblies as materials was chronologically covered. Certain challenging uses of nanomaterials, for example, the use of nanoparticles for brain targeting, their interaction with cells, using nanoneedles to understand cell–surface interactions, and nanostraws for direct cell delivery were highlighted. Furthermore, a few talks focused on the use of novel nanosystems for tackling viral infections/diseases, for which a cure remains inaccessible for the larger part. In addition, emphasis was laid on translational aspects of nanomedicine, i.e., transferring research from laboratory to the clinics, giving a realistic perspective to the ongoing research in the field of nanomedicine.
Translational Trends in Nanomedicine
Beilstein Nanotechnology Symposium 2018
17 – 19 September, 2018
Hotel Jagdschloss Niederwald, Ruedesheim, Germany
Scientific Program:
Joerg Lahann / University of Michigan
Luis Liz-Marzán / CIC biomaGUNE, San Sebastian
Francesco Stellacci / EPFL, Lausanne
Molly Stevens / Imperial College London
Summary
From nanomaterials to peptide assemblies, important considerations with respect to their cellular interactions and in turn their toxic effects were presented. An insight into the biological activity relationship of rare earth oxides that are used for bioimaging was an interesting perspective for all researchers as it concerns most work done in the field of nanotoxicity.
Apart from the scientific talks, an excellent poster session covered a range of topics from the design of nanomaterials such as nanoneedles and nanoparticles, to their applications in cell transfection and for nanomedicine, respectively. This interactive session was the perfect platform for young researchers to engage with their peers and professors for initiating collaborations and developing further ideas for their research. Taking full advantage of the beautiful venue, we enjoyed a pleasant hiking trip through the vineyards tasting authentic wine from the region.
In a nutshell, the symposium on “Translational Trends in Nanomedicine” was a rewarding experience in terms of research excellence, scientific discussions, selected group of participants, outstanding location, and a wonderful and engaging atmosphere!
Scientific Program
Talks
MONday, 17 SEPTEMBER
9:00
Welcome and Introduction
Session chair: Francesco Stellacci
9:20
Brain-targeting nanoparticles
Joerg Lahann / University of Michigan, USA
10:00
Nanoparticles for cell tracking applications: some basic considerations
Neus Feliu / University of Hamburg, Germany
10:40
Coffee break
11:10
Degradation of nanoparticles effects their colloidal properties and interaction with cells
Wolfgang Parak /University of Hamburg, Germany
11:50
Imaging with plasmonic nanoparticles
Luis Liz-Marzán /CIC biomaGUNE, Spain
12:30
Lunch
Session chair: Luis Liz-Marzán
13:50
Use of composite nanoparticles for the inhibition of viral infections
Ronit Sarid / Bar-Ilan University, Israel
14:30
Multivalent nanosystems as potent influenza virus inhibitors
Daniel Lauster / Free University of Berlin, Germany
15:10
Coffee break
15:40
Nanotechnology to develop novel antivirals
Francesco Stellacci / EPFL, Switzerland
16:20
POSTER INTRODUCTION
Short presentation of all posters
POSTER SESSION
18:00
Presentation and discussion of all posters
20:00
Dinner
TUESDAY, 18 SEPTEMBER
Session chair: Nicholas Melosh
9:00
Bio-responsive hybrid materials for regenerative medicine and biosensing
Molly M. Stevens / Imperial College London, UK
9:40
Nanomedicine based on DNA hybrid materials and supercharged polypeptides
Andreas Herrmann / DWI - Leibniz Institute for Interactive Materials, Germany
10:20
Coffee break
10:50
Crystallization pathways for protein crystals and colloidal assemblies
Sharon C. Glotzer / University of Michigan, USA
11:30
Targeting drug carriers in the vasculature
Vladimir Muzykantov / University of Pennsylvania, USA
12:10
Lunch
13:50
EXCURSION
17:30
End of excursion
19:00
Dinner
WEDNESday, 19 SEPTEMBER
Session chair: Molly M. Stevens
9:00
Emerging concepts in clinical nanomedicine: hemodynamics and modulation of innate immunity
Joy Wolfram / Mayo Clinic, USA
9:40
Supramolecular engineering strategies to bridge nanoscale design and macroscopic applications
Alvaro Mata / Queen Mary University of London, UK
10:20
Coffee break
10:50
Nanophotonic metasurfaces for next generation biosensors
Hatice Altug / EPFL, Switzerland
11:30
Nanostraw mediated non-perturbative cell access and transfection
Nicholas Melosh / Stanford University, USA
12:10
Lunch
Session chair: Joerg Lahann
13:30
Biomimetic nanostructures as functional biomaterials
Nicholas A. Kotov / University of Michigan, USA
14:10
Non-invasive elastic property measurement of soft matter
John Kieffer / University of Michigan, USA
14:50
Coffee break
15:20
Peptide-triggered gene transfer in musculoskeletal regeneration
Millicent O. Sullivan / University of Delaware, USA
16:00
Integrated nanosafety considerations in developing nanomedicine applications
Tian Xia / University of California, USA
16:40
Final words, farewell
16:50
End of program
19:00
Dinner
Poster
No. 1:
Exploring new nanoneedle techniques for enhanced cell transfection
Michele Becce / Imperial College London
No. 2:
Protein-mediated synthesis of anisotropic nanoparticles and their application as ROS scavengers
Mustafa ElGharib / University of Hamburg
No. 3:
The use of 3D cell models to investigate nanomedicine uptake and imaging thereof
Malou Henriksen-Lacey / CIC biomaGUNE
No. 4:
Virucidal nanomaterials targeting influenza virus
Özgün Kocabıyık / EPFL
No. 5:
Detection of metabolic interactions in the tumour environment by surface-enhanced resonance Raman scattering
Javier Plou / CIC biomaGUNE
No. 6:
Fabrication of functional nanostructured materials for patterned
bio-immobilization
Divya Varadharajan / Karlsruhe Institute of Technology
No. 7:
Towards controlled polymer brushes for nanomedicine
Gowthamy Venkidasubramonian / Karlsruhe Institute of Technology
No. 8:
Integrity of dye conjugated iron oxide nanoparticles in presence of different enzymes
Lin Zhu / University of Hamburg