Synthesis of Sugars
A basic requirement of glycomics is the ability to synthesize carbohydrates. This is much more difficult than, for example, creating proteins from amino acids, because the carbohydrates are very complex and bonds are hard to build. The synthesis of carbohydrates and the discovery of structure–function relationships are major scientific challenges that can lead to new drugs and medical treatments.
Carbohydrates against Malaria
The tailor-made synthesis of carbohydrates from sugar molecules is nowadays part of standard procedures thanks to advances in automation. Peter Seeberger, who co-developed these methods, held a lecture at the Beilstein Bozen Symposium 2006, where he presented an outlook on the production of carbohydrate-based vaccines against malaria.
Syntheses in the Glycosciences
Carbohydrates are natural products whose syntheses are considered particularly difficult. The exploration of synthetic methods and the study of the relationships between their structure and biological effect is regarded as a particular challenge. Thisbe Lindhorst from Kiel University edited two thematic series on glycosciences in the Beilstein Journal of Organic Chemistry. A total of 48 articles were published.