Introduction

One-pot processes have considerably enhanced diversity-oriented syntheses in the past decades and have become an enabling tool for providing myriads of substance libraries, in particular, in pharmaceutical high-throughput screening and lead finding. Over the past two decades, we have paved the way of multicomponent reactions (MCR) as a synthetic concept to access functional p-electron systems, such as chromophores, fluorophores, and electrophores, by scaffold and chromophore approaches. Transition metal catalyzed couplings are excellent entries to alkynones, which can be transformed by multi-component and domino processes to various classes of functional fluorescent chromophores in a one-pot fashion (chromophore concept). In the lecture the general concept is introduced and illustrated by the development of ethynyl quinoxalines and aroyl-S,N-ketene acetals, novel classes of polar solid-state and aggregation-induced emissive dyes.

References

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