Preparation of active pharmaceutical ingredients by mechanochemistry

Evelina Colacino / University of Montpellier

January 20, 2021, 2 - 3 pm CET

Online live talk


The recent development of mechanical–chemical strategies as alternative means to activate chemical processes has allowed access to new, more environmentally sustainable strategies to prepare organic molecules or pharmaceutically relevant fragments and functionalities, paving the way to medicinal mechanochemistry.

Selected examples for the eco-conscious preparation of hydantoin-based active pharmaceutical ingredients (APIs) will be presented, highlighting the advantages of mechanochemical process, and its scalability by reactive twin-screw extrusion (TSE), allowing the continuous manufacturing of pharmaceuticals products.

Evelina Colacino

Evelina Colacino is Associate Professor of Organic and Green Chemistry since 2013, at the University of Montpellier, France. Her main research activities concern the development of eco-friendly methodologies for the preparation of biomolecules, heterocyclic compounds and hybrid materials by mechanochemistry (dry or wet grinding), with a main focus on hydantoin scaffold and active pharmaceutical ingredients (medicinal mechanochemistry). She also investigates sustainable approaches to homogeneous or heterogeneous metal-catalysed processes by combining enabling technologies (ultrasounds, microwaves, and flow systems) with non-conventional media [e.g., glycerol, water, poly(ethylene)glycols, and PEG-based ionic liquids] or in micellar conditions (in water and glycerol).

She is also a promoter of sustainability in higher education by integrating green chemistry at undergraduate level in organic chemistry courses, with a special focus on the fundamentals and the practice of mechanochemistry.

Since 2019, she leads the European Programme COST Action CA18112 (Mech@SustInd) – "Mechanochemistry for Sustainable Industry" ( and


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