The Beilstein Talks are a new addition to the Beilstein-Institut’s projects supporting communication and information in science. Experts are invited to present an overview and latest research results on topics in organic chemistry, nanotechnology or open science and answer questions from the audience. These online lectures are free to attend; a simple registration is all that is required. Interested scientists from all over the world are invited to join us and participate in the
Beilstein Talks.

Nanomedicine at the crossroads
Why good chemistry is not enough

Matthias G. Wacker / National University of Singapore

November 18, 2020, 2 - 3 pm CET

Free registration for the online talk


Nowadays, an emerging number of advanced therapies conquer the global market and, around the world, improve patients’ quality of life. Nanotechnology-related drug products are at the forefront of this development showing significant market potential and groundbreaking opportunities in cancer therapy.

Still the translation of nanomedicines from bench to bedside poses a major challenge to the scientific community. Key challenges arise from the bioanalytical methods required to characterize nanomedicines in preclinical and clinical studies. The talk provides a snapshot of our research activities in the characterization of nanomedicines in vitro and in silico. In this context, model-informed drug development has been effective in establishing a direct relationship between the physicochemical and in vitro properties of injectable nanocarriers and the in vivo performance seen during the phase I pharmacokinetic studies. Major hurdles in the development of novel drug delivery systems and their translation into the hospital will be discussed from the perspective of a pharmaceutical scientist.

Matthias G. Wacker

Matthias G. Wacker is Associate Professor in the Department of Pharmacy of the National University of Singapore (NUS). Initially, he studied Pharmacy at Goethe University in Frankfurt (Germany) where he obtained his doctoral degree in pharmaceutical technology. As a post-doc and group leader he has joined Jennifer Dressman and Jörg Kreuter in the Institute of Pharmaceutical Technology, Goethe University. There he accomplished his habilitation exploring the ‘Rational Formulation Design of Nanocarrier Devices’ and was awarded the venia legendi in pharmaceutical technology. Prior to joining NUS, he was heading the Department of Pharmaceutical Technology and Nanosciences of the Fraunhofer-Institute for Molecular Biology and Applied Ecology in Frankfurt. Currently, he serves the European Journal of Pharmaceutics and Biopharmaceutics and the Journal of Pharmacy and Pharmacology as an editorial board member and is scientific advisor to the editors of the Journal of Pharmaceutical Sciences.

Further, he was a guest editor of the thematic issue "Frontiers in pharmaceutical nanotechnology" in the Beilstein Journal of Nanotechnology honoring the life achievements of Prof. Jörg Kreuter, Goethe University. In recognition of his research excellence, he was honored with the Eudragit® Best Paper Award (2014) and the Phoenix Pharmaceutics Science Award (2017). Currently, he is chairing the Nanomaterial Working Group of the Expert Panel on New Advancements in In-Vitro Product Performance Testing of the United States Pharmacopeial Convention. His research focuses on the design of novel nanocarriers based on a quality-by-design approach by using a combination of in vitro performance testing and model-informed drug development.


The Beilstein Talks are organized by the Beilstein-Institut.
If you have any questions, please contact:

Dr. Michael Penk
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