Organic synthesis has advanced remarkably in its ability to construct pharmaceutical ingredients, natural products, agrochemicals, ligand architectures, and functional building blocks for materials science. Yet many established methodologies continue to rely on labor-intensive protecting-group strategies and costly purification steps inherent to classical “stop-and-go” workflows. The upcoming symposium “SIMPLE STARTS, COMPLEX ENDS: THE POWER OF ONE-POT CHEMISTRY” will bring together researchers at the forefront of synthetic innovation to discuss how multi-component one-pot methodologies are redefining efficiency, selectivity, and sustainability in modern chemistry.
The program will explore how multi-step one-pot reactions and autonomous one-flask processes offer powerful alternatives to traditional routes, enabling the rapid generation of structural complexity from simple starting materials. Topics will include catalytic domino sequences with high functional-group tolerance, streamlined protocols that eliminate intermediate isolation, and strategies that approach the ideal of Pot, Atom, and Step Economy (PASE). These advances illustrate how reaction cascades contribute to greener synthesis by reducing waste, time, and operational demands.
