Nanomedicine is the medical application of nanotechnology achieved by combining nano- and biomaterials with the future perspective to address pathologies in a complex and heterogeneous scenario.

The challenge of nanomedicine depends on the use of nano- and biomaterials at the nanometer scale to manufacture scalable drug delivery systems and medical devices that are safe, biocompatible and non-toxic. The goal is to selectively target microenvironments and tissues through physiological and pathological mechanisms that modulate the micro- and macro environments of patients affected by rare and clinically relevant pathologies. The combination of nano- and biomaterials, the modification of interface properties, as well as the functionalization of the resulting drug delivery systems with macromolecules and active biomolecules, provides specific properties for tailoring precision medicine. This boosts the application for many diseases with suitable therapeutic options and benefits for the patients.

In this symposium, we will address the latest advances of nanomedicine for precise targeting therapies and unlock their potential for drug and gene delivery applications. The selected talks will provide valuable insights on the latest developments of translational research on nanomedicine for a personalized therapy and towards a reliable pre-clinical and clinical assessment.

The symposium will cover, but is not limited to the following themes:

 

The water-soluble fullerenes for pancreatic cancer treatment
Maciej Serda / University of Silesia, Katowice, Poland

In vivo in situ engineered BMSCs promote bone healing through gene silencing
Yang Wu / Åbo Akademi University, Turku, Finland

In situ generating CO gas for destroying bacterial biofilms
Pengzhen Zhuang / Åbo Akademi University, Turku, Finland

Phase-transforming nanodroplets for acoustically enhanced mRNA delivery
Haikun Liu / Baker Heart & Diabetes Institute, Melbourne, Australia

Platelet-membrane bubbles: Dual functionality ultrasound contrast and precision clot-targeting agents
Mark Vidallon / Baker Heart and Diabetes Institute, Melbourne, Australia

Composite functional vesicles induce “find-me/eat-me” in macrophages to regulate RA disease
Yu Zhang / Åbo Akademi University, Turku, Finland

The combination of 2D (graphene oxide) immunomodulators and fibrin hydrogels as a neoadjuvant for post-resection glioblastoma
Despoina Despotopoulou / Catalan Institute of Nanoscience and Nanotechnology, Barcelona, Spain

Enhancing the relaxivity properties of magnetic nanoparticles by rational control of the local magnetic environment
Brindusa Dragoi / Regional Institute of Oncology Iasi, Iasi, Romania

Physiology-inspired multilayer nanofibrous membranes modulating endogenous stem cell recruitment and osteo-differentiation for staged bone regeneration
Yu Chen / Åbo Akademi University, Turku, Finland

Bio-inspired porous microneedles dwelled stem cells for diabetic wound treatment
Lu Fan / Åbo Akademi University, Turku, Finland

Self-healing dynamic hydrogel microparticles with structural color for wound management
Li Wang / Åbo Akademi University, Turku, Finland

Magnetic iron oxide nanoparticles for antimycobacterial application
Motunrayo Badejo / Stellenbosch University, Cape Town, South Africa

Self-assembled gold nanoclusters for bio-photonic applications
Furhan Abdul Rezak / Université Grenoble Alpes, Grenoble, France

Biodegradable polyphosphoester micelles act as both background-free ³¹P magnetic resonance imaging agents and drug nanocarriers
Olga Kohskina / Phos4nova B.V., Enschede, Netherlands

Chitosan functionalized Mn3O4 nanoparticles counteract ulcerative colitis in mice through modulation of cellular redox state
Susmita Mondal / S. N. Bose National Centre for Basic Sciences, Kolkata, India

Green synthesis and characterization of hyaluronic acid-modified selenium nanoparticles for melanoma therapy
Luigia Serpico / University Medical Center Groningen (UMCG), Groningen, Netherlands

Active targeting of molecularly imprinted polymers to MCF7 breast cancer cells, dual drug delivery and biosensing
Preetha Ganguly / Indian Institute of Technology Delhi, India

Refining iron supplementation: preparation, optimization & characterization of liposomal delivery systems
Lina Livrinska / Ss. Cyril and Methodius University, Skopje, North Macedonia

Heterodimeric peptide-based building blocks for nanoparticle functionalization
Julien Draussin / Institut de cancérologie Strasbourg Europe, France

Protein corona mitigates the cytotoxic effects of nanoplastics on SK-BR-3 cells
Siyao Xiao / Sapienza University of Rome, Italy

Designing stealth bio-nano-architectures: Structuring lipid nanoparticles, DNA, and protein corona for in vivo gene delivery
Serena Renzi / Sapienza University of Rome, Italy

DNA condensing agent enhances CAR-T cell transfection efficiency of DNA-loaded lipid nanoparticles
Andrea Pirrottina / Sapienza University of Rome, Italy

Advanced mixing technology for the synthesis of small and stable mRNA-loaded lipid nanoparticles
Annika Brehmer / Fraunhofer-Institute for Production Systems and Design Technology IPK, Berlin, Germany

“Cytosolic’’ nanoprobes? First replication initiative in nanobioscience
Mustafa ElGharib / Université Sorbonne Paris Nord, France

Nanotechnology in medicine: promises of intracellular use vs precise localisation of nanomaterials
Nathanne Rost / Université Sorbonne Paris Nord, France