Unparalleled diversity and functionality of the glycome

Beilstein Glyco-Bioinformatics Symposium 2023

June 20 - 22, 2023

Dom Hotel, Limburg, Germany

The Glyco-Bioinformatics Symposium 2023 brought together glycochemists and biologists with experts in bioinformatics and computer sciences.


Scientific Committee:

Carole Creuzenet / University of Western Ontario

Elisa Fadda / Maynooth University

Benjamin Schumann / Imperial College London

Carsten Kettner / Beilstein-Institut


Follow us on Twitter: #BeilsteinGlyco2023


This symposium broght together glycochemists and biologists with experts in bioinformatics and computer sciences not only to look back at the roots of glycosciences
30 odd years ago but also to gather the perspectives of present and future applications of glycomics.

Glycomics, in the past considered a subfield of proteomics, has established itself and evolved to become an independent discipline which studies systematically the structures and functions of glycans in a cell or organism.

Consequently, boundaries to proteomics, genomics and metabolomics are crossed towards a systems-wide investigation of the various roles of glycoconjugates in cell-cell communication, recognition processes, signal transduction, molecular trafficking, modulation and regulation of molecular pathways in both eukaryotes and prokaryotes and in many other processes such as diagnosis and therapy of diseases. Glycomics also encompasses further important areas, for example, combining bioinformatics and mathematics approaches to develop methods for data storage, analysis, and modelling functions and relationships.

Under the guidance of the MIRAGE Commission, this conference series also provides a platform to discuss current standards and needs for additional standards in the glycoscience. The mission of MIRAGE (www.beilstein-mirage.org) is to establish guidelines for the reliable and accurate reporting of glycan data and to interconnect existing and future infrastructure entities to provide the glycoscience community services for the deposition, sharing, analysis and reuse of glycan data.

The following aspects have been covered


/glycan-linked diagnosis and therapy (markers and vaccines)

/methods for analysis and identification of glycoconjugates

/structure-function relationships of glycosylation patterns

/the metabolic art of directed glycosylation

/software tools for analysis and identification

/integration of data from glycomics, proteomics and genomics resources



Conference Photo

Scientific Program

Schedule | Posters | Software


Tuesday, June 20


Welcome and Opening
Carsten Kettner

Session chair: Benjamin Schumann

The Diversity and Functionality of the Cancer Glycome: From Molecular Mechanisms to the Clinical Applications
Celso Reis, University of Porto

Glycoproteomic Landscape and Structural Dynamics of TiM Family Immune Checkpoints Enabled by Mucinase SmE
Stacy Malaker, Yale University

Software Lightning Talks
Software #1-7

Coffee break and Software demo

Regulation of N-linked Glycosylation Site Occupancy
Ben Schulz, University of Queensland

Autonomous Optimization of Glycosylations Generates Reliable Data for Machine Learning Approaches to Reaction Prediction
Peter Seeberger, Max Planck Institute of Colloids and Interfaces, Potsdam


Session chair: Elisa Fadda

Information Transfer in Mammalian Glycan-based Communication
Christoph Rademacher, University of Vienna

Map of Neuronal Tissue O-glycosites Reveal Specific Traits in the Secretogranin Family
Katrine Schjoldager, University of Copenhagen

Poster Lightning Talks #1
Posters #1-8

Conference photo, Coffee break and Poster session

Poster Lightning Talks #2
Posters #9-17

Synthesis and Function of Capsular Modified Heptoses in Campylobacter jejuni
Carole Creuzenet, University of Western Ontario

Chemical Evolution of Enzyme-catalyzed Glycosylation
Hongzhi Cao, Ocean University of China




Wednesday, June 21



Session chair: Carole Creuzenet

Mucin-derived Glycans as Regulators of Pathogen Virulence
Rachel Hevey, University of Basel

S-Layer Glycosylation Patterns of Tannerella Species in Oral Health versus Disease Effectors and Effects
Christina Schäffer, University of Natural Resources and Life Sciences, Vienna

Coffee break and Software demo

Structural Insights into the Function of Toxoplasma gondii Mucin-type O-glycosyltransferase GalNAc-T3
Nadine Samara, NIH-NIDCR, Bethesda

Measuring Glycoprotein Host-pathogen Interactions by Single-molecule Mass Imaging and Tracking
Weston Struwe, University of Oxford

Chemical Precision Tools Reveal the Surprising Biology of SARS-CoV-2 O-glycosylation
Benjamin Schuman, Imperial College London


14:00 - 18:00



Thursday, June 22



Session chair: Niclas Karlsson

The Diversity of the Glycan Shield of Sarbecoviruses Related to SARS-CoV-2
Joel Allen, University of Southampton

Sugars as Key Elements of Archetypical Biopolymers Motifs
Elisa Fadda, Maynooth University

Coffee break and Poster session

Making Glycodata as FAIR as Possible
Frédérique Lisacek, Swiss Institute of Bioinformatics, Geneva

The Glycan Array Data Repository
René Ranzinger, University of Georgia

New Native Mass Spectrometry Tools for Glycomics
John S. Klassen, University of Alberta


Session chair: Dani Ungar

Full-stack Glycoinformatics: From Data to Insight
Daniel Bojar, University of Gothenburg

Exploring Functional Impact of Single Nucleotide Variations through Integration of Genomic and Glycosylation Site Specific Data in GlyGen
Raja Mazumder, George Washington University

Coffee break

Applying Transcriptomics to Study Glycosylation at the Cell Type Level
Hiren Joshi, University of Copenhagen

Studying the Mechanism of Bacterial Protein Glycosylation
Marthe Walvoort, University of Groningen

Elucidating Bacteria Toxin and Mucin Binding Domains - Specificities Towards Mucin-O-Glycopeptides
Ulrika Westerlind, University of Umeå

Closing Remarks
Carsten Kettner


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No. 1

Exploring Protein N-glycosylation Alterations between Wild-type and Mutant Forms of Irisin
Joseph Zaia, Boston University

No. 2

Towards the Development of a Spatio-temporal O-Glycosylation Reporter Systems
Abdul H. Zafar, Imperial College London

No. 3

Modelling the Processing of Glycans on Secreted Glycoproteins
Daniel Ungar, University of York

No. 4

Mapping Glycosyltransferases Glycosylation Sites and Substrate Preferences via Glycoproteomics
Lucia Di Vagno, Imperial College London

No. 5

Evolution of the Interactions between Rotavirus VP8* and HBGAs: Insights from Computational Studies
Jesús Rodriguez-Diaz, University of Valencia

No. 6

Fine-tuning the Spike: Role of the Glycan Shield in the Structure / Dynamics of SARS-CoV-2S
Carl Fogarty, Maynooth University

No. 7

Simple, yet Logical Terms of N-glycans Meet the Emergence of Isomer-sensible Analysis
Friedrich Altmann, University of Natural Resources and Life Sciences, VIenna

No. 8

Towards Clinical O-glycomics: Application for Osteoarthrithis
Niclas Karlsson, Oslo Metropolitan University

No. 9

Exploring the Glycoproteome of the Sheep Myiasis Fly, Lucilia cuprina, for Novel Vaccine Targets
Edward Kerr, CSIRO, Brisbane


No. 10

Elucidating the O-glycan Structure of Tannerella serpentiformis
Stephanie Walcher, University of Natural Resources and Life Sciences, Vienna

No. 11

Wholistic Heparan Sulphate Oligosaccharide Profiling Using Top-down GAGomics
Marissa L. Maciej-Hulme, University of California San Diego

No. 12

Development of a Machine Learning Framework to Extract the Biomarker Potential of IgG N-glycans
Konstantinos Flevaris, Imperial College London

No. 13

Serum N-glycan Biomarkers Predict Patient Response to Vedolizumab Treatment for Crohn’s Disease
Georgia Elgood Hunt, Ludger Ltd., Oxford

No. 14

Integrated Glycomics and Genomics Reveals a Role for Plasma Protein and IgG N-glycosylation in Type 1 Diabetes Development
Najda Rudman, University of Zagreb

No. 15

Linking Glycosylation to Function
Catherine Hayes, Swiss Institute of Bioinformatics, Geneva

No. 16

Bioinformatics Analyses of Nematode Hexosaminidases
Zuzanna Dutkiewicz, University of Natural Resources and Life Sciences, Vienna

No. 17

A Bacterial Mannose Binding Lectin as a Tool for the Enrichment of C-and O-Mannosylated Peptides
Hans Bakker, Hannover Medical School

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No. 1

Privateer - Validation of Modelled Glycosylaton in the 3D Structural Biology Frontier
Haroldas Bagdonas, University of York

No. 2

Automated Glycopeptide Data Processing and Curation in Ghih Sensitivity Applications
David Falck, Leiden University Medical Center

No. 3

A Demonstration of CarbArrayART, a Tool for Glycan Microarray Data Management and Reporting
Yukie Akune, Imperial College London

No. 4

What's new on Glyco@Expasy?
Frédérique Lisacek, Swiss Institute of Bioinformatics, Geneva

No. 5

GlycoDomainViewer, Glycopacity and Glyco.me
Hiren J. Joshi, University of Copenhagen

No. 6

GlyFinder: An Online Tool for Finding Glycans and Glycoproteins in the PDB
Robert Woods, University of Athens, USA

No. 7

GlyGen Portal, Glycan Array Data Repository and the Glycoinformatics Consortium
René Ranzinger, University of Athens, USA



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