In spring 2020, the spread of SARS CoV-2 caused the 8th Warren Workshop to be cancelled and the organizers decided to postpone this popular meeting by another year. However, this would have meant colliding with another popular meeting, the Beilstein GlycoBioinformatics Symposium.
Online
Joint Warren and Beilstein Symposium
on
Glycosciences
June 23 - 25, 2021
The Joint Warren and Beilstein Symposium on Glycosciences 2021 was held online and brought together glycochemists and biologists with experts in bioinformatics and computer sciences.
Scientific Committee:
Anne Imberty / Université Grenoble Alps
Carsten Kettner / Beilstein-Institut
Frédérique Lisacek / Swiss Institute of Bioinformatics, Geneva
Sylvie Ricard-Blum / Université de Lyon
Overview
Thus, the organisers of both conferences decided to make a virtue of necessity and merge their events to provide a common platform which will bring together glycochemists and glycobiologists with experts in bioinformatics and computer sciences to gather the recent advances in glycoconjugate analysis, structure and bioinformatics.
Topics 2021
The following aspects have been covered:
- complexity of glycomolecules,
- chemical tools for synthesizing and analysis of glycans,
- profiling glycans as markers to detect viruses, pathogens etc.,
- cell walls and cell surfaces,
- glycans in three dimensions,
- software tools for data storage, analysis, mining and sharing,
- synthetic glycobiology
Scientific Program
Wednesday, June 23
Welcome and opening
10.45 am (CEST), 5.45 am (EDT), 2.45 am (PDT), 5.45 pm (JST), 6.45 pm (AEST)
Session 1.1:
Chemical Biology Tools
11.00 am (CEST), 6.00 am (EDT), 3.00 am (PDT), 6.00 pm (JST), 7.00 pm (AEST)
Chaired by: Sabine Flitsch and Anne Imberty
Complex glycans as scaffolds for the preparation of potent C-type lectin inhibitors
Niels Reichardt
Chemical precision tools to study the glycoproteome
Ben Schumann
Glycan microarrays - much needed tools for understanding microbe-host interactions
Yan Liu
Poster session 1 and
Networking session (Meet the Speakers) 1
12.15 am (CEST), 7.15 am (EDT), 4.15 am (PDT), 7.15 pm (JST), 8.15 pm (AEST)
Session 1.2:
Profiling Glycans
1.00 pm (CEST), 7.00 am (EDT), 4.00 am (PDT), 8.00 pm (JST), 9.00 pm (AEST)
Chaired by: Kiyoko Aoki-Kinoshita and Frédérique Lisacek
Multi-omics of MLL-rearranged B-cell precursor acute lymphoblastic leukemia reveals broad glycoproteom remodeling
Daniel Kolarich
Measuring spike protein glycosylation similarity during viral evolution
Joseph Zaia
Glycomics and glycoproteomics analysis of complex biological systems
Stuart Haslam
Hyphenated IM-MS methods for carbohydrate sequencing
Sabine Flitsch
Glyspace
2.45 pm (CEST), 8.45 am (EDT), 5.45 am (PDT), 9.45 pm (JST), 10.45 pm (AEST)
Chaired by: Carsten Kettner
Contributions of the GlyCosmos Portal towards the GlySpace Allliance and standardized glycoscience data
Kiyoko Aoki-Kinoshita
GlyGen - a knowledge base for glycomics and glycoproteomics
René Ranzinger
Glycomics@expasy: SIB's portal supporting glycoscience
Julien Mariethoz
Software demo 1
3.45 pm (CEST), 9.45 am (EDT), 6.45 am (PDT), 10.45 pm (JST),11.45 pm (AEST)
Networking session (Meet the Speakers) 2
4.45 pm (CEST), 10.45 am (EDT), 7.45 am (PDT), 11.45 pm (JST), 0.45 am (Thursday, AEST)
6.00 pm (CEST)
Close of the first day
Thursday, June 24
Software demo 2
10.00 am (CEST), 4.00 am (EDT), 1.00 am (PDT), 5.00 pm (JST), 6.00 pm (AEST)
Session 2.1:
Cell Walls and Cell Surfaces
11.00 am (CEST), 5.00 am (EDT), 2.00 am (PDT), 6.00 pm (JST), 7.00 pm (AEST)
Chaired by: Jerry Eichler and Anne Imberty
Unveiling the puzzle of structure and function of glycans
Alba Silipo
Electron microscopy methods for structural characterization of crystalline charbohydrates and plant cell walls
Yu Ogawa
Synthetic carbohydrate-based materials
Martina Delbianco
Networking session (Meet the Speakers) 3
12.15 pm (CEST), 6.15 am (EDT), 3.15 am (PDT), 7.15 pm (JST), 8.15 pm (AEST)
Session 2.2:
Complexity of Glycomolecules
1.15 pm (CEST), 8.15 am (EDT), 5.15. am (PDT), 8.15 pm (JST), 9.15 pm (AEST)
Chaired by: Alba Silipo and Carsten Kettner
Glycosylation in giant viruses
Cristina de Castro
N-glycosylation in archaea: so many ways to be sweet
Jerry Eichler
Targeting modified heptose synthesis to prevent Campylobacteriosis
Carole Creuzenet
Networking session (Meet the Speakers) 4
2.30 pm (CEST), 8.30 am (EDT), 5.30 am (PDT), 9.30 pm (JST), 10.30 pm (AEST)
Session 2.3:
New Tools for the Glycoworld
3.15 pm (CEST), 10.15 am (EDT), 7.15 am (PDT), 10.15 pm (JST), 11.15 pm (AEST)
Chaired by: Ben Schumann and Frédérique Lisacek
SynGlycan reagents for longitudinal, non-destructive measurement of the glycome
Sriram Neelamegham
Insights into influenza virus infectoin by using NMR spectroscopy
María Ángeles Canales
The differing challenges of intact N- and O-glycopeptide data searching
Robert Chalkley
Poster session 2 and
Networking session (Meet the Speakers) 5
4.30 pm (CEST), 10.30 am (EDT), 7.30 am (PDT), 11.30 pm (JST), 0.30 am (Friday, AEST)
5.30 pm (CEST)
Close of the second day
Friday, June 25
Session 3.1:
Glycans in Three Dimensions
11.00 am (CEST), 5.00 am (EDT), 2.00 am (PDT), 6.00 pm (JST), 7.00 pm (AEST)
Chaired by: Serge Perez and Sylvie Ricard-Blum
Computational insights into modeling protein-glycosaminoglycan interactions
Sergey Samsonov
Integrative glycan model building and validation
Jon Agirre
Glycosylation as a means to modulate membrane receptor conformation and visibility
Ilpo Vattulainen
Functional role of the glycan shield in the activiation of the SARS-CoV-2 S protein
Elisa Fadda
Session 3.2:
Clinical and Biomedical World
12.45 pm (CEST), 6.45 am (EDT), 3.45 am (PDT), 7.45 pm (JST), 8.45 pm (AEST)
Chaired by: Pauline Rudd and Frédérique Lisacek
The effects of O-GlcNAcylation on mitochondrial function and the neurodegenerative process
Gavin Davey
From concept to first-in-Human phase I study and beyond for a monovalent Shigella synthetic glycan-based conjugate vaccine candidate
Laurence Mulard
Networking Session (Meet the Speakers) 6
1.30 pm (CEST), 7.30 am (EDT), 4.30 am (PDT), 8.30 pm (JST), 9.30 pm (AEST)
Session 3.3:
Synthetic Glycobiology
2.15 pm (CEST), 8.15 am (EDT), 5.15 am (PDT), 9.15 pm (JST), 10.15 pm (AEST)
Chaired by: Elisa Fadda and Sylvie Ricard-Blum
Why are proteins O-GalNAc-glycosylated?
Hans Wandall
Achievement of stable protein sialylation in Physcomitrella
Eva Decker
O-Acetylation: adding the cherry on top of the sugar cake
Martina Mühlenhoff
Deciphering and engineering the genetic bases of glycosylation through systems biology
Nathan Lewis
Networking session (Meet the Speakers) 7
4.30 pm (CEST), 10.30 am (EDT), 7.30 am (PDT), 11.30 pm (JST), 0.30 am (Saturday, AEST)
5.00 pm (CEST)
Conclusions
The organizers
Posters
|
No. |
Title |
Presenter |
|
PS1 |
Improved Glycopeptide Identification using High-field Asymmetric Waveform Ion Mobility Spectrometry (FAIMS) |
K. Alagesan |
|
PS2 |
Human Lectome : A new module for protein structure prediction in Unilectin database |
J. El Ahmadi |
|
PS3 |
O-glycan sulfation on ovarian cancer cyst fluid mucin-type proteins |
N. Karlsson |
|
PS4 |
Janus lectins as a scaffold for double specificity |
S. Notova |
|
PS5 |
Chemical Synthesis and Immunological Evaluation of Novel TACA-αGalCer Cancer Vaccines |
C. Romano |
|
PS6 |
A histo-blood group antigen appeared methylated on N-glycans from oysters Crassostrea gigas and Ostrea edulis. |
A. Auger |
|
PS7 |
The Oligomannose N-glycans 3D Architecture and its Response to the FcγRIIIa Structural Landscape |
C. Fogarty |
|
PS8 |
The need for community standards to enable accurate comparison of glycoproteomics algorithm performance |
W. Hackett |
|
PS9 |
Deciphering glycopeptidolipid glycosylation to characterize macrophage invasion by Mycobacterium abscessus |
L.-D. Leclercq |
|
No. |
Title |
Presenter |
|
PS10 |
Cracking the ErbB2 Sugar Code in Gastric Cancer - A Bitter Sweet Functional Target |
H. Oliviera Duarte |
|
PS11 |
Modulation of cystatin F glycosylation impacts its localization and activity of cathepsin C |
E. Senjor |
|
PS12 |
Janus lectin mediated liposomal fusion to cancer cells |
L. Siukstaite |
|
PS13 |
Glycosyltransferase at work: The insights from coarse-grained molecular dynamics simulations |
O. Makshakova |
|
PS14 |
A histo-blood group antigen appeared methylated on N-glycans from oysters Crassostrea gigas and Ostrea edulis |
A. Auger |
|
PS15 |
Hexosaminidase (HEX-4) ‚ a new biochemical tool for glycan analysis |
Z. Dutkiewicz |
|
PS16 |
Reverse engineering of GlycoCT format for application in RDF model of glycan structures |
C. Hayes |
|
PS17 |
Novel glyco epitopes from fruiting bodies of wild type Dictyostelium species |
A. Hykollari |
|
PS18 |
Effects of desialylation on Insulin receptor dynamics |
R. Mallenahalli-Rao |
Software Demos
|
No |
Title |
Presenter |
|
SW1 |
Glycowork |
D. Bojar |
|
SW2 |
Differentiation of heparan sulfate oligosaccharide positional isomers using liquid chromatography-ion mobility-mass spectrometry |
G. Caval |
|
SW3 |
CarbArrayART |
Y. Akune |
|
No. |
Title |
Presenter |
|
SW4 |
GlyFinder (dev.glycam.org/gf) |
D. Montgomery |
|
SW5 |
Glycologue (https://glycologue.org) |
A. McDonald |
