Online

Joint Warren and Beilstein Symposium

on

Glycosciences

 

June 23 - 25, 2021

 

The Joint Warren and Beilstein Symposium on Glycosciences 2021 was held online and brought together glycochemists and biologists with experts in bioinformatics and computer sciences.

 

 

Scientific Committee:

Anne Imberty / Université Grenoble Alps

Carsten Kettner / Beilstein-Institut

Frédérique Lisacek / Swiss Institute of Bioinformatics, Geneva

Sylvie Ricard-Blum / Université de Lyon

Overview

In spring 2020, the spread of SARS CoV-2 caused the 8th Warren Workshop to be cancelled and the organizers decided to postpone this popular meeting by another year. However, this would have meant colliding with another popular meeting, the Beilstein GlycoBioinformatics Symposium.

Thus, the organisers of both conferences decided to make a virtue of necessity and merge their events to provide a common platform which will bring together glycochemists and glycobiologists with experts in bioinformatics and computer sciences to gather the recent advances in glycoconjugate analysis, structure and bioinformatics.

Topics 2021

The following aspects have been covered:

 

  • complexity of glycomolecules,
  • chemical tools for synthesizing and analysis of glycans,
  • profiling glycans as markers to detect viruses, pathogens etc.,
  • cell walls and cell surfaces,

 

  • glycans in three dimensions,
  • software tools for data storage, analysis, mining and sharing,
  • synthetic glycobiology

Scientific Program

 

Wednesday, June 23

 

Welcome and opening

10.45 am (CEST), 5.45 am (EDT), 2.45 am (PDT), 5.45 pm (JST), 6.45 pm (AEST)

 

Session 1.1:
Chemical Biology Tools

11.00 am (CEST), 6.00 am (EDT), 3.00 am (PDT), 6.00 pm (JST), 7.00 pm (AEST)

Chaired by: Sabine Flitsch and Anne Imberty

Complex glycans as scaffolds for the preparation of potent C-type lectin inhibitors
Niels Reichardt

Chemical precision tools to study the glycoproteome
Ben Schumann

Glycan microarrays - much needed tools for understanding microbe-host interactions
Yan Liu

 

Poster session 1 and
Networking session (Meet the Speakers) 1

12.15 am (CEST), 7.15 am (EDT), 4.15 am (PDT), 7.15 pm (JST), 8.15 pm (AEST)

 

Session 1.2:
Profiling Glycans

1.00 pm (CEST), 7.00 am (EDT), 4.00 am (PDT), 8.00 pm (JST), 9.00 pm (AEST)

Chaired by: Kiyoko Aoki-Kinoshita and Frédérique Lisacek

Multi-omics of MLL-rearranged B-cell precursor acute lymphoblastic leukemia reveals broad glycoproteom remodeling
Daniel Kolarich

Measuring spike protein glycosylation similarity during viral evolution
Joseph Zaia

Glycomics and glycoproteomics analysis of complex biological systems
Stuart Haslam

Hyphenated IM-MS methods for carbohydrate sequencing
Sabine Flitsch

 

Glyspace

2.45 pm (CEST), 8.45 am (EDT), 5.45 am (PDT), 9.45 pm (JST), 10.45 pm (AEST)

Chaired by: Carsten Kettner

Contributions of the GlyCosmos Portal towards the GlySpace Allliance and standardized glycoscience data
Kiyoko Aoki-Kinoshita

GlyGen - a knowledge base for glycomics and glycoproteomics
René Ranzinger

Glycomics@expasy: SIB's portal supporting glycoscience
Julien Mariethoz

 

Software demo 1

3.45 pm (CEST), 9.45 am (EDT), 6.45 am (PDT), 10.45 pm (JST),11.45 pm (AEST)

 

Networking session (Meet the Speakers) 2

4.45 pm (CEST), 10.45 am (EDT), 7.45 am (PDT), 11.45 pm (JST), 0.45 am (Thursday, AEST)

 

6.00 pm (CEST)

Close of the first day

 

Thursday, June 24

 

Software demo 2

10.00 am (CEST), 4.00 am (EDT), 1.00 am (PDT), 5.00 pm (JST), 6.00 pm (AEST)

 

Session 2.1:
Cell Walls and Cell Surfaces

11.00 am (CEST), 5.00 am (EDT), 2.00 am (PDT), 6.00 pm (JST), 7.00 pm (AEST)

Chaired by: Jerry Eichler and Anne Imberty

Unveiling the puzzle of structure and function of glycans
Alba Silipo

Electron microscopy methods for structural characterization of crystalline charbohydrates and plant cell walls
Yu Ogawa

Synthetic carbohydrate-based materials
Martina Delbianco

 

Networking session (Meet the Speakers) 3

12.15 pm (CEST), 6.15 am (EDT), 3.15 am (PDT), 7.15 pm (JST), 8.15 pm (AEST)

 

Session 2.2:
Complexity of Glycomolecules

1.15 pm (CEST), 8.15 am (EDT), 5.15. am (PDT), 8.15 pm (JST), 9.15 pm (AEST)

Chaired by: Alba Silipo and Carsten Kettner

Glycosylation in giant viruses
Cristina de Castro

N-glycosylation in archaea: so many ways to be sweet
Jerry Eichler

Targeting modified heptose synthesis to prevent Campylobacteriosis
Carole Creuzenet

 

Networking session (Meet the Speakers) 4

2.30 pm (CEST), 8.30 am (EDT), 5.30 am (PDT), 9.30 pm (JST), 10.30 pm (AEST)

 

Session 2.3:
New Tools for the Glycoworld

3.15 pm (CEST), 10.15 am (EDT), 7.15 am (PDT), 10.15 pm (JST), 11.15 pm (AEST)

Chaired by: Ben Schumann and Frédérique Lisacek

SynGlycan reagents for longitudinal, non-destructive measurement of the glycome
Sriram Neelamegham

Insights into influenza virus infectoin by using NMR spectroscopy
María Ángeles Canales

The differing challenges of intact N- and O-glycopeptide data searching
Robert Chalkley

 

Poster session 2 and
Networking session (Meet the Speakers) 5

4.30 pm (CEST), 10.30 am (EDT), 7.30 am (PDT), 11.30 pm (JST), 0.30 am (Friday, AEST)

 

5.30 pm (CEST)

Close of the second day

 

Friday, June 25

 

Session 3.1:
Glycans in Three Dimensions

11.00 am (CEST), 5.00 am (EDT), 2.00 am (PDT), 6.00 pm (JST), 7.00 pm (AEST)

Chaired by: Serge Perez and Sylvie Ricard-Blum

Computational insights into modeling protein-glycosaminoglycan interactions
Sergey Samsonov

Integrative glycan model building and validation
Jon Agirre

Glycosylation as a means to modulate membrane receptor conformation and visibility
Ilpo Vattulainen

Functional role of the glycan shield in the activiation of the SARS-CoV-2 S protein
Elisa Fadda

 

Session 3.2:
Clinical and Biomedical World

12.45 pm (CEST), 6.45 am (EDT), 3.45 am (PDT), 7.45 pm (JST), 8.45 pm (AEST)

Chaired by: Pauline Rudd and Frédérique Lisacek

The effects of O-GlcNAcylation on mitochondrial function and the neurodegenerative process
Gavin Davey

From concept to first-in-Human phase I study and beyond for a monovalent Shigella synthetic glycan-based conjugate vaccine candidate
Laurence Mulard

 

Networking Session (Meet the Speakers) 6

1.30 pm (CEST), 7.30 am (EDT), 4.30 am (PDT), 8.30 pm (JST), 9.30 pm (AEST)

 

Session 3.3:
Synthetic Glycobiology

2.15 pm (CEST), 8.15 am (EDT), 5.15 am (PDT), 9.15 pm (JST), 10.15 pm (AEST)

Chaired by: Elisa Fadda and Sylvie Ricard-Blum

Why are proteins O-GalNAc-glycosylated?
Hans Wandall

Achievement of stable protein sialylation in Physcomitrella
Eva Decker

O-Acetylation: adding the cherry on top of the sugar cake
Martina Mühlenhoff

Deciphering and engineering the genetic bases of glycosylation through systems biology
Nathan Lewis

 

Networking session (Meet the Speakers) 7

4.30 pm (CEST), 10.30 am (EDT), 7.30 am (PDT), 11.30 pm (JST), 0.30 am (Saturday, AEST)

 

5.00 pm (CEST)

Conclusions
The organizers

 

Posters

 

No.

Title

Presenter

PS1

Improved Glycopeptide Identification using High-field Asymmetric Waveform Ion Mobility Spectrometry (FAIMS)

K. Alagesan

PS2

Human Lectome : A new module for protein structure prediction in Unilectin database

J. El Ahmadi

PS3

O-glycan sulfation on ovarian cancer cyst fluid mucin-type proteins

N. Karlsson

PS4

Janus lectins as a scaffold for double specificity

S. Notova

PS5

Chemical Synthesis and Immunological Evaluation of Novel TACA-αGalCer Cancer Vaccines

C. Romano

PS6

A histo-blood group antigen appeared methylated on N-glycans from oysters Crassostrea gigas and Ostrea edulis.

A. Auger

PS7

The Oligomannose N-glycans 3D Architecture and its Response to the FcγRIIIa Structural Landscape

C. Fogarty

PS8

The need for community standards to enable accurate comparison of glycoproteomics algorithm performance

W. Hackett

PS9

Deciphering glycopeptidolipid glycosylation to characterize macrophage invasion by Mycobacterium abscessus

L.-D. Leclercq

No.

Title

Presenter

PS10

Cracking the ErbB2 Sugar Code in Gastric Cancer - A Bitter Sweet Functional Target

H. Oliviera Duarte

PS11

Modulation of cystatin F glycosylation impacts its localization and activity of cathepsin C

E. Senjor

PS12

Janus lectin mediated liposomal fusion to cancer cells

L. Siukstaite

PS13

Glycosyltransferase at work: The insights from coarse-grained molecular dynamics simulations

O. Makshakova

PS14

A histo-blood group antigen appeared methylated on N-glycans from oysters Crassostrea gigas and Ostrea edulis

A. Auger

PS15

Hexosaminidase (HEX-4) ‚ a new biochemical tool for glycan analysis

Z. Dutkiewicz

PS16

Reverse engineering of GlycoCT format for application in RDF model of glycan structures

C. Hayes

PS17

Novel glyco epitopes from fruiting bodies of wild type Dictyostelium species

A. Hykollari

PS18

Effects of desialylation on Insulin receptor dynamics

R. Mallenahalli-Rao

Software Demos

No

Title

Presenter

SW1

Glycowork

D. Bojar

SW2

Differentiation of heparan sulfate oligosaccharide positional isomers using liquid chromatography-ion mobility-mass spectrometry

G. Caval

SW3

CarbArrayART

Y. Akune

No.

Title

Presenter

SW4

GlyFinder (dev.glycam.org/gf)

D. Montgomery

SW5

Glycologue (https://glycologue.org)

A. McDonald