From Molecular Mechanisms to High-Performance Systems

Beilstein Enzymology Symposium 2023

September 12 – 14, 2023

Hotel Jagdschloss Niederwald, Rudesheim, Germany

Scientific Committee:

Edda Klipp / Humboldt University, Berlin
Joelle Pelletier / Université de Montreal
Jürgen Pleiss / University of Stuttgart
Carsten Kettner / Beilstein-Institut

Topics 2023

/structure and functions revised (e.g., the past, the presence and future of enzymology, biocatalysis, synthetic and systems biology),

/insights into enzyme mechanisms (e.g., promiscuous enzymes, tunnelling, reactions under extreme conditions, non-obvious modifiers),

/directed evolution and cascades (e.g., engineered enzymes, disordered proteins, moonlighting roles),

/upstream and downstream of reaction cascades (e.g., regulation of pathways and multi-enzyme cascades),

/prediction of structures and functions (e.g., data driven modelling and mining, incl. AI, structure prediction based on genomics and meta-genomics),

/high-performance systems and interesting applications.

Scientific Program

Schedule | Posters

Tuesday, Sept. 12

9:00
Welcome and Opening
Carsten Kettner

Session chair: Jürgen Pleiss

9:20
Enzyme Kinetics: Still a Valuable Tool for Shedding Light on Regulation, Mechanism, and Even Structure
María Luz Cárdenas, Athel Cornish-Bowden, CNRS-BIP, Marseille

10:10
Enzymology Under New-to-nature Conditions
John Woodley, Technical University Denmark

10:50
Poster Lightning Talks
Poster numbers 1,3,4,5

11:15
Coffee break and Poster session

11:45
Thermodynamic Considerations on Enzyme Kinetics in Biochemical Reaction Networks
Edda Klipp, Humboldt University Berlin

12:25
Elucidation of the Biosynthetic Pathways for the Construction of the Capsular Polysaccharides in the Human Pathogen Campylobacter jejuni
Frank Raushel, Texas A&M University

13:05
Lunch

Session chair: John Richard

14:20
A Tail of Tails - The Remarkable SULT2B1b
Thomas S. Leyh, The Albert Einstein College of Medicine

15:00
Coenzyme A Metabolism in Inherited Disorders of Fatty-acid Metabolism
Barbara Bakker, University Medical Center Groningen

15:40
Poster Lightning Talks
Poster numbers 6-11

16:10
Conference photo, Coffee break and Poster session

16:40
When Nature Stumbles on a Good Thing: From Promiscuous Binding to Essential Enzyme Activity
Joelle Pelletier, Université de Montréal

17:20
(Re)designing Enzymes as Therapeutics and Biosensors
Karen Allen, Boston University

18:00
Evolution of Energy Landscapes and its Exploitation for Enzyme and Drug Design
Dorothee Kern, Brandeis University

18:40
Close

19:30
Dinner

Wednesday, Sept. 13

9:00
Opening

Session chair: Santiago Schnell

9:05
Stepping into the Universe of Proteoforms
Hartmut Schlüter, University Medical Center Hamburg

9:45
Reinventing Pathways: Convergent Evolution of Specialized Metabolites in Flowering Plants
Tobias Köllner, MPI for Chemical Ecology, Jena

10:25
Poster Lightning Talk
Poster number 2

10:40
Coffee break

11:10
Predicting the Effects of Mutations in Proteins by Data-driven Methods
Stanislav Mazurenko, Masaryk University, Brno

11:50
The EnzymeML Toolbox: Digitalization of Biocatalysis by Scalable Workflows and FAIR Data
Jürgen Pleiss, University of Stuttgart

12:30
STRENDA: What, Why, How and Where to?
Johann Rohwer, University of Stellenbosch

13:10
Lunch

14:00 - 18:00
Excursion

19:30
Dinner

Thursday, Sept. 14

9:00
Opening

Session chair: Edda Klipp

9:05
Approaches to the Design of Protein Folds and Functions
Birte Höcker, University of Bayreuth

9:45
Can we Computationally Design Efficient Enzymes?
Sílvia Osuna, Universitat de Girona

10:25
Software Lightning Talk

10:45
Coffee break

11:15
Design Meets Evolution: Theory and Practice for Fine-tuned Bioengineering
Victor de Lorenzo, Centro Nacional de Biotecnologia, Madrid

11:55
Use of Mechanistic Understanding to Improve Enzyme Performance
Pimchai Chaiyen, Vidyasirimedhi Institute of Science and Technology (VISTEC), Rayong

12:35
Enzymes for Sustainable Biomanufacturing - Expanding the Molecular Repertoire and Getting there Faster
Ee Lui Ang, A-STAR, Singapore

13:15
Lunch

Session chair: Joelle Pelletier

14:30
Features and Adaptation Strategies of Cold-active Enzymes
Marina Lotti, University of Milano

15:10
Improvement of α-amino Ester Hydrolase Stability via Computational Protein Design
Andreas Bommarius, Georgia Institute of Technology, Atlanta

15:50
Coffee break

16:20
Tuning Multi-enzyme Catalysed processes – Modular Set-up, Activity Regulation, and Integration with Microbial and Chemical Transformations
Dörte Rother, Research Center Jülich

17:00
Biocatalysis and Beyond: Developing (Photo)enzymatic Strategies for more Sustainable Synthesis
Sandy Schmidt, University of Groningen

17:40
Photocatalytic Enzymes by Design and Evolution
Adrian Bunzel, ETH Zürich

18:20
Closing Remarks
Carsten Kettner

19:30
Dinner

Posters

No. 1

Cyanobacterial Indole Alkaloid Biosynthesis: Exploring the Role of Rieske Oxygenases
Niels de Kok, University of Groningen

No. 2

What is Life Like in vivo? Standards for Enzymology
Hans V. Westerhoff, Universities of Amsterdam

No.3

Triosephosphate Isomerase: The Crippling Effect of the P168A/I172A Substitution at the Heart of an Enzyme Active Site
John Richard, University of Buffalo

No. 4

Structure-function Relationships in NDP-sugar Active SDR Enzymes: Fingerprints for Functional Annotation and Enzyme Engineering
Koen Beerens, Ghent University

No. 5

Structure-driven Drug Discovery of Human NADPH Oxidases Specific Inhibitors
Sara Marchese, University of Pavia

No. 6

Needs for and Challenges in the Analysis of Proteoforms
Bente Siebels, Universitätsklinikukm Hamburg-Eppendorf

No. 7

Computational Design of Enantioselective Photoenzymes Using Deep Learning
Florence Hardy, University of Manchester

No. 8

openTECR - the Open Database on Thermodynamics of Enzyme-catalyzed Reactions
Robert Giessmann, Institute for Globally Distributed Open Research and Education, Gothenburg

No. 9

Immobilizing Mutant Xylosidase by Cross-linked Enzymatic Aggregates and onto Chitosan Support through Entrapment or Covalent Bonding
Jeff Wilkesman, University of Applied Sciences Mannheim

No. 10

Sequence-Dynamics-Function Relationships in Protein Tyrosine Phosphatases
Michael Robinson, University of Uppsala

No. 11

Prediction of Protein Interaction Sites in the mTOR Signalling Network
Yin-Chen Hsieh, UiT The Arctic University of Norway, Tromsø