Enzymes in Transformation and Signalling

Beilstein ENZYMology Symposium 2017

19 21 September 2017

Hotel Jagdschloss Niederwald, Rüdesheim, Germany


Scientific Committee:

Barbara Bakker / University Medical Center Groningen

Carsten Kettner / Beilstein-Institut

Thomas S. Leyh / The Albert Einstein College of Medicine, New York

Ming-Daw Tsai / Academia Sinica, Taipeh

The Beilstein Enzymology Symposium 2017 (formerly Beilstein ESCEC Symposium) brought together biochemists, enzymologists and systems biologists with experts in bioinformatics and computer sciences.

Topics 2017

  • transcriptional and translational machines
  • regulation and control of information transfer
  • effects of damages and deficiencies
  • manipulation by viruses and bacteria
  • signal transduction and cascades
  • inter-connection of metabolism with information transfer
  • conversion of matter into energy and vice versa


Time-resolved measurements of the molecular activities of enzymes during catalysis correlate the conformational and chemical events that occur during the catalytic cycle.  Beyond catalysis of isolated enzymes, such measurements are used to elucidate the coordinated interactions of proteins with larger macromolecules and assemblages, which often require precise spatiotemporal positioning of the partners within the greater context of the cell to faithfully execute higher order cellular functions. Gene expression is often triggered in response to extra- or intracellular stimuli, such as light, gravity, nutrients, toxins, hormones, etc. Enzymes and other signal‑cascade proteins capture and transduce these diverse signals into discrete chemical entities that inform and direct cellular behaviour. Molecular-information processing networks require the coordinated interplay of numerous components, and are the focus of systems-biological investigations aimed at understanding, for example, the spread of disease, or identifying targets that can control signal-transduction.

The Beilstein Enzymology Symposia embrace structural, computational and biological disciplines, and bring researchers (established and younger workers) together to discuss the many and diverse roles of enzymes in biology, and to explore the limits and challenges of holistic studies that attempt to integrate microscopic views of protein function into complex biological behaviour. Under the guidance of the STRENDA Commission, this conference series also provides a platform to discuss current standards in biochemistry.  The mission of STRENDA is to establish guidelines for the reliable and accurate reporting of protein function data, and to create a database (STRENDA DB) to capture and disseminate this data as it enters the literature. All participants are encouraged to discuss their latest results, approaches and methodologies in experimental, theoretic and bioinformatics enzymology.

SCientific Programm

Structural Mechanism for the Fidelity Modulation of DNA Polymerases
Ming-Daw Tsai, Academia Sinica, Taipei, Taiwan

Insights from a Global Analysis of the Structure-function Relationships in the Tautomerase Superfamily
Christian P. Whitman, The University of Texas at Austin

Poster Flash Presentations

Interleukin-6 and ADAM17 in the Control of Inflammation and Cancer
Stefan Rose-John, University of Kiel

Structural Basis for Regulation in the Aromatic Amino Acid Hydroxylases
Paul F. Fitzpatrick, University of Texas Health Science Center, San Antonio, TX

Viral-encoded Receptor Proteins Rewire Cellular Signalling
Martine J. Smit, VU Universiteit Amsterdam

A Novel Role for Small Non-coding RNA in the DNA Damage Response: Characterization of DROSHA Recruitment to DNA Breaks
Sofia Francia, IFOM - The FIRC Institute of Molecular Oncology, Milano

Transcription Initiation Complex and Genetic Disorders
Jean-Marc Egly, University of Strasbourg

The Dynamic Epigenome: Mechanisms Governing Stepwise Oxidation of 5-mathylcytosine by TET Family Enzymes
Rahul Kohli, University of Pennsylvania, Philadelphia, PA

Enzyme Conformational Dynamics Control HIV Reverse Transcriptase Specificity and Evolution of Drug Resistance
Kenneth A. Johnson, The University of Texas at Austin

Poster Session

How Integrated Annotation in Diverse Databases with Enzyme Information Can Provide Translational Science
Claire O'Donovan, EMBL-EBI, Cambridge

CETCH Me If You Can: Bringing Inorganic Carbon into Life with Synthetic CO2 Fixation
Tobias Erb, MPI for Terrestrial Microbiology, Marburg

Adaptation of Phosphatases as Regulators, Catalysts, and Housekeepers
Karen N. Allen, Boston University

Evolutionary Diversification of Protein-protein Interactions by Interface Add-ons
Reinhard Sterner, University of Regensburg

Design and Evolution of New Biocatalysts for Enantionselective Synthesis
Nicholas Turner, The University of Manchester

Design and Evolution of Artificial Enzymes
Donald Hilvert, ETH Zurich

Nature's Strategies in the Regulation of Enzyme Activity by Modifiers Examined under the Magnifying Glass
Antonio Baici, University of Zurich

Multi-level Regulation of Metabolic Enzymes During Biological Ageing
Barbara M. Bakker, University Medical Center Groningen

Biosynthesis of the O-Methyl Phosphoramidate Modifications to the Capsular Polysaccharides of Campylobacter jejuni
Frank M. Raushel, Texas A&M University, College Station, TX

Sulfuryl-transfer — Catalysis and Biology
Thomas S. Leyh, Albert-Einstein College of Medicine, Bronx, NY

How to Break a Carbon-Fluorine Bond — Assymmetry, Dynamics, Selectivity, and Inhibition in a Dehalogenation Reaction
Emil F. Pai, University of Toronto

Translational Control: Probing Dimensionality Beyond Linear Sequence of mRNA
Zoya Ignatova, University of Hamburg

Metabolic Regulation from the Optimality Perspective
Bas Teusink, VU Universiteit Amsterdam

SABIO-RK: From Experiment to Database to Analysis
Wolfgang Müller, Heidelberg Institute for Theoretical Studies

Designing Enzyme Assays for the Accurate Measurement of Enzyme Kinetic Parameters
Santiago Schnell, University of Michigan Medical School, Ann Arbor, MI

STRENDA DB: The 'PDB' for Enzyme Function Data?
Johann Rohwer, University of Stellenbosch

Poster Presentations

Relationship Between Active Site Loop Dynamics and Catalysis in Indole-3-glycerol Phosphate Synthase
Sandra Schlee

Library Selection with a Radomized Repertoire of Phosphate-binding (ba)8-barrel Enzymes
Bettina Rohweder

Molecular Engineering and Directed Evolution of Human LAsparaginases: Improving Current Enzyme-based Therapy of Acute Lymphoblastic Leukemia
Manfred Konrad

Informatics for the Design-Build-Test-Learn Cycle Applied to the Directed Evolution of Enzymes
Neil Swainston

Photo Gallery

Photos taken by Ulrike Wittig