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worked on enzyme kinetics 1950–1963, was an administrator at the University of Wisconsin 1963–1967, was an administrator at MIT 1967–1982, did research on the thermodynamics of petroleum processing 1982–1992, research on biochemical thermodynamics 1992–2006, and has recently been working on enzyme kinetics. He has been a coauthor of a textbook on physical chemistry for 50 years, and has written two books on biochemical thermodynamics. He feels fortunate that his experience in petroleum thermodynamics prepared him to work on biochemical thermodynamics, and his work on biochemical thermodynamics prepared him to work on enzyme kinetics. Sometimes it is a good idea to get out of your field to work in a related field because when you come back to your earlier field you will see it with new eyes.
is a Team Leader and Senior Scientist at the European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK. He studied Biology with a focus on Biochemistry and Molecular Biology in Heidelberg, Germany and Bath, UK, and worked in drug discovery in the pharmaceutical industry. He became involved in Bioinformatics through the Swiss-Prot project in 1987. He received his PhD in 1994 from the Center for Molecular Biology, University of Heidelberg, Germany and joined the European Bioinformatics Institute the same year. Dr Apweiler has coordinated the Swiss-Prot work at the European Bioinformatics Institute since 1994. He also started, among other projects, the TrEMBL protein database, the Integrated resource of protein families, domains and functional sites (InterPro), Gene Ontoloy Annotation (GOA), the Integr8 web portal, the Genome Reviews, and the UniProt resource (the sucessor of the Swiss-Prot, TrEMBL and PIR projects). These projects have organised large amounts of protein information, provided comparisons between proteomes and aim to produce dynamic, controlled vocabularies that can be applied to all organisms. In addition, Dr Apweiler has been in charge of the EMBL nucleotide sequence database since 2001. Dr Apweiler served on many review and editorial boards and published more than hundred peer-reviewed articles and numerous book chapters. Rolf Apweiler has also a long-standing interest in data standards and nomenclature as exemplified in his engagement in the IUBMB Nomenclature Committee, the HUGO gene nomenclature committee, and in the HUPO Proteomics Standards Initiative.
Education
1970: |
B.S. Western Illinois University, Chemistry, Macomb, Illinois |
1975: |
Ph.D. Marquette University, Organic Chemistry Milwaukee, Wisconsin (with Prof. N. E. Hoffman) |
1976–1978: |
Postdoctoral Fellow, University of Chicago, Chicago, Illinois (with Prof. E. T. Kaiser) |
1990: |
Sabbatical Leave, Center for Advanced Research in Biotechnology, Rockville, MD, Protein Crystallography (with Gary Gilliland) |
Positions Held
since |
1997: Professor, Department of Chemistry, Vanderbilt University, College of Arts & Sciences |
since 1995: |
Professor, Department of Biochemistry and the Center in Molecular Toxicology, Vanderbilt University School of Medicine |
1990–1995: |
Professor, Department of Chemistry & Biochemistry, UMCP |
1988–1990: |
Chair, Biochemistry Division, UMCP |
1985–1990: |
Associate Professor, Department of Chemistry & Biochemistry, UMCP |
1980–1985: |
Assistant Professor, Department of Chemistry University of Maryland, College Park |
1978–1980: |
Staff Fellow, Laboratory of Bioorganic Chemistry, NIAMDD, National Institutes of Health, Bethesda, Maryland |
1976–1978: |
Postdoctoral Fellow, Department of Chemistry, University of Chicago, Chicago, Illinois |
115 publications (refereed articles, book chapters, reviews), more than 120 invited lectures.
Research Interests
Functional genomics. Enzymatic basis of antibiotic resistance. Mechanism and stereochemistry of enzyme-catalyzed reactions. Metabolism and detoxification of drugs and toxic compounds. Protein structure and function and engineering. Protein crystallography. Applications of physical organic chemistry to biochemical and biotechnological problems. Stereochemistry and conformations of strained molecules.
is Professor of Biochemistry at King's College, University of London. He was a Major Open Scholar at Jesus College, University of Cambridge, from where he graduated with a BA in Natural Sciences in 1965 and PhD in Enzymology in 1968, under the supervision of Malcolm Dixon. His research has centred on the use of spectroscopic techniques to study mechanisms of electron transfer and enzyme catalysis, particularly in complex iron-sulfur proteins. He is past Chairman (2000–2005) of the Nomenclature committee of the International Union of Biochemistry and Molecular Biology (IUBMB) and Joint commission on Biochemical Nomenclature (JCBN), and Editor-in-Chief of the second edition of the Oxford Dictionary of Biochemistry and Molecular Biology. He has published two books, and over 220 research papers. He is currently investigating aspects of the role of iron in health and disease.
carried out his undergraduate studies at Oxford, obtaining his doctorate with Jeremy R. Knowles in 1967. After three post-doctoral years in the laboratory of Daniel E. Koshland, Jr., at the University of California, Berkeley, he spent 16 years as Lecturer, and later Senior Lecturer, in the Department of Biochemistry at the University of Birmingham. Since 1987 he has been Directeur de Recherche in three different laboratories of the CNRS at Marseilles. Although he started his career in a department of organic chemistry virtually all of his research has been in biochemistry, with particular reference to enzymes, including pepsin, mammalian hexokinases and enzymes involved in electron transfer in bacteria. He has written several books relating to enzyme kinetics, including Analysis of Enzyme Kinetic Data (Oxford University Press, 1995) and Fundamentals of Enzyme Kinetics (3rd edition, Portland Press, 2004).
Since moving to Marseilles he has been particularly interested in multi-enzyme systems, including the regulation of metabolic pathways. At present his main interest is in the definition of life and the capacity of living organisms for self-organization. In addition his principal areas of research, he has long had an interest in biochemical aspects of evolution, and his semi-popular book in this field, The Pursuit of Perfection, was published by Oxford University Press in 2004.
received his Bachelor of Arts (Chemistry Major) from Johns Hopkins University and his Doctor of Philosophy (Physical Chemistry) from Carnegie-Mellon University. After completion of a post-doctoral research fellowship at Mellon Institute and the University of Pittsburgh, he joined the National Institute of Standards and Technology (formerly the National Bureau of Standards) in 1969. His primary areas of expertise include chemical thermodynamics, calorimetry and equilibrium measurements, data evaluation, thermodynamics of solutions, biochemical thermodynamics, analytical microcalorimetry, and chromatography. A major focus of his research has been on the thermodynamics of enzyme-catalyzed reactions. This has resulted in the determination of the thermodynamic parameters for a large number of such reactions – including a substantial number of the most important reactions pertinent to physiology and to metabolism as well as reactions that are of major industrial interest. These studies involve the combined use of equilibrium and calorimetric measurements coupled with thermodynamic modeling calculations. The information obtained allows for the prediction of the position of equilibrium of the studied reaction(s) over wide ranges of temperature, pH, and ionic strength.
Recent research has included studies of biochemical reactions in non-aqueous solvents, redox reactions, and reactions in the shikimate and chorismate pathways.
Codes for performing equilibrium calculations on systems of biochemical reactions have also been developed and published. The entire field involving the thermodynamics of enzyme-catalyzed reactions has been surveyed and the data extracted and made available on the web: http://xpdb.nist.gov/enzyme_thermodynamics/. He has been active in IUPAC, ASTM, and in the U.S. Calorimetry Conference. He is a recipient of the Measurement Services Award of the National Institute of Standards and Technology.
is Professor in the Department of Biochemistry at the University of Stellenbosch, South Africa. He obtained his Ph.D. in 1986at the University of Stellenbosch after collaborating with Henrik Kacser (one of the founders of metabolic control analysis) and the enzymologist Athel Cornish-Bowden. Jannie and his colleagues Jacky Snoep and Johann Rohwer form the Triple-J Group for Molecular Cell Physiology, a research group that studies the control and regulation of cellular processes using theoretical, computer modelling and experimental approaches. He has made numerous fundamental contributions to the development of metabolic control analysis and computational cell biology, and with Athel Cornish-Bowden developed both co-response analysis and supply-demand analysis as a basis for understanding metabolic regulation. He is a Fellow of the Academy of Science of South Africa and, with the other Triple-Js, chairs the International Study Group for BioThermoKinetics. He recently won the Harry Oppenheimer Fellowship Award, South Africa’s most prestigious science award.
studied biology at the University of Bonn and obtained his diploma at the University of Göttingen in the group of Prof. Gradmann which had the pioneering and futuristic name – “Molecular Electrobiology”. This group consisted of people carrying out research in electrophysiology and molecular biology in fruitful cooperation. In this mixed environment, he studied transport characteristics of the yeast plasma membrane using patch clamp techniques. In 1996 he joined the group of Dr. Adam Bertl at the University of Karlsruhe and undertook research on another yeast membrane type. During this period, he successfully narrowed the gap between the biochemical and genetic properties, and the biophysical comprehension of the vacuolar proton-translocating ATP-hydrolase. He was awarded his Ph.D for this work in 1999. As a post-doctoral student he continued both the studies on the biophysical properties of the pump and investigated the kinetics and regulation of the dominant plasma membrane potassium channel (TOK1). In 2000 he moved to the Beilstein-Institut to represent the biological section of the funding department. Here, he is responsible for the organization of symposia (Beilstein-Symposium and ESCEC), research (proposals) and development of new products such as MedPhyt, a medicinal plants database. Since 2004 he coordinates the work of the STRENDA commission and promotes along with the commissioners the proposed standards of reporting enzyme data. In 2007 he became involved in the invention of a program for the establishment of Beilstein Endowed Chairs for Chemical sciences and related sciences.
Originally trained as a biochemist, Sandra Orchard spent a number of years working as an enzymologist for Roche Products Ltd, eventually becoming the Team Leader of a group looking at protein kinases as potential drug targets. She moved to the European Bioinformatics Institute in 2002, originally as a UniProtKB/Swiss-Prot curator but also worked on the InterPro and Gene Ontology databases before initiating the curation of the molecular interaction database IntAct of which she is now the curation coordinator.
Sandra has been involved in the work of the Human Proteome Organisation Proteomics Standards Initiative since its initiation, and is now a member of the Steering Committee.
is Associate Professor in the Department of Biochemistry at Stellenbosch University, South Africa. He obtained his Ph.D. in 1997 from the University of Amsterdam, working on the control and regulation of the bacterial phosphotransferase system under the supervision of Hans Westerhoff. He then joined Stellenbosch University, where he and his colleagues Jannie Hofmeyr and Jacky Snoep constitute the “Triple-J Group for Molecular Cell Physiology”, a research group that studies the control and regulation of cellular processes using theoretical, numerical and experimental approaches.
Johann has contributed to the theoretical development of metabolic control analysis, to its experimental application, and to the development of software tools for computational systems biology. His main research interests are the construction of kinetic models of cellular function with a particular emphasis on plant central carbon metabolism, and the application of NMR spectroscopy to the non-invasive study of metabolism in vivo. He has received the President's Award from the South African National Research Foundation and the Silver Medal of the South African Society of Biochemistry and Molecular Biology. Together with the other Triple-Js, he has chaired the BTK: International Study Group for Systems Biology, and he represents his university on the South African National Bioinformatics Network.
was born in Indianapolis, Indiana and acquired her B.S. degree in chemistry at Harvey Mudd College in 1985. She obtained her Ph.D. in the laboratory of Paul A. Bartlett at UC Berkeley in 1990 and then carried out postdoctoral research in the laboratory of Jeremy R. Knowles at Harvard University. Nicole joined the faculty at Stony Brook University in 1993 and is currently a Professor of Chemistry, as well as a member of the graduate programs in Pharmacology, Biochemistry & Structural Biology, and Biophysics. Her research interests are in the areas of mechanistic enzymology and chemical biology. Her work presently focuses on catalysis by cholesterol–modifying enzymes, how they modify the lipid bilayer and their role in bacterial pathogenesis, and probing protein–protein interactions in mammalian fertilization using synthetic molecules, in particular functionalized polymers.
Sampson’s honors and awards include the Camille and Henry Dreyfus New Faculty Award, an NSF CAREER Award, the ACS Arthur C. Cope Scholar Award and the Pfizer Award in Enzyme Chemistry.
Her research program has been supported by the National Institutes of Health, the Petroleum Research Fund, the National Science Foundation, the American Heart Association, the Dreyfus Foundation, Biogen, and Bristol-Myers Squibb.
Institution and Position:
Charité – University Medicine Berlin
Senior Scientist and Head of the Core-Facility Protein-Purification
1988: |
Diploma (=M.Sc.) in Biochemistry, Faculty of Chemistry, University of Münster |
1991: |
Ph.D. (Dr. rer. nat.) in Biochemistry, University of Münster, Faculty of Chemistry, Thesis supervisor: Prof. Dr. H. Witzel |
1994: |
Heinz Maier-Leibnitz prize |
1995: |
Gerhard Hess award (DFG) |
1995: |
Bennigsen-Foerder prize |
1991–1996: |
Postdoctoral fellowship at the Medical Faculty of the University of Münster |
1996: |
Habilitation (Dr. rer. nat. habil.) in Pathobiochemistry at the Medical Faculty of the University of Münster |
1996–2000: |
Group leader at the Medical Faculty of the Ruhr-University of Bochum |
2000 – current: |
Senior Scientist and Head of the Bioanalytical Laboratory of Nephrology, Charité – University Medicine Berlin, Campus Benjamin-Franklin, Joint Facility of the Free University of Berlin and the Humboldt-University of Berlin |
2003 – current: |
Professor at the Charité, Campus Benjamin-Franklin, University-Medicine Berlin |
2003 – current: |
Member of the board of the Center for Functional Genomics – Berlin-Brandenburg (http://www.cffg.de/) |
2004: |
Head of the Core-Facility Protein Purification |
2005: |
Founding member of the Mass-Spec-Net Berlin-Brandenburg (www.massspecnet.de) |
Working field:
1974: |
Diplom in Chemistry at the Technical University “Carolo-Wilhelmina” in Braunschweig |
1976: |
Dr. rer. nat. in Chemistry (Structural Chemistry of Organo-phosphorus compounds) |
1985: |
Habilitation (Dr. rer. nat. habil.) for Structural Chemistry |
Scientific Career:
1976–1978: |
Post-Doc in the Chemistry Department at Technical University Braunschweig. |
1978–1979: |
Research Fellow at Harvard University in Cambridge, Mass., U. S. A. in Professor W.N. Lipscomb's and Professor F.H. Westheimer's groups. |
1979–1981: |
Post-Doctoral Fellow in the Chemistry Department at Braunschweig Technical University |
1981–1983: |
Assistant Professor (Hochschulassistent), Braunschweig Technical University |
1983–1986: |
Head of the x-ray lab at the German Centre for Biotechnology – GBF (Gesellschaft für Biotechnologische Forschung), Braunschweig |
1987–1996: |
Head of the GBF Department of “Molecular Structure Research.” |
1989–1995: |
Head of CAPE (Center of Applied Protein Engineering) |
1990–1996: |
(apl.) Professor at the Technical University Braunschweig |
1996–2007: |
Full Professor of Biochemistry, University of Cologne |
since 2007: |
Full Professor of bioinformatics & biochemistry, Technical University Braunschweig |
received his PhD in 1992 in the fields of microbial physiology and enzymology working on the control of pyruvate catabolism in bacterial systems. He subsequently worked as a postdoctoral fellow, first specializing in molecular techniques to apply control analysis together with Prof Ingram at the University of Florida and later together with Prof Westerhoff at the Netherlands Cancer Instuitute working on theoretical and modelling aspects of biological systems.
Currently Snoep is appointed at the University of Stellenbosch (Biochemistry), at the Vrije Universiteit in Amsterdam (Cellular Bioinformatics) and at the University of Manchester (Integrative Systems Biology).
His research aim is to get a quantitative understanding of cellular physiology, i.e. to attribute systemic (cellular) properties to characteristics of the underlying components (enzymes). Due to the complexity (non-linear interactions) and complicatedness (multitude of interactions) the research subjects necessitate a combined approach of precise and quantitative experimentation, computer modelling and a robust theoretical framework such as Metabolic Control Analysis. Research topics range from simple ecosystems to metabolic engineering of lactic acid bacteria, to the control of metabolic pathways such as glycolysis, to the control of DNA supercoiling.
was born in Neuwied, Germany, in 1966. He studied chemistry at the University of Bonn, where he received his diploma and doctoral degree in the workgroup of Prof. Eberhard Breitmaier at the Institute of Organic Chemistry. Focus of his Ph. D. thesis was the program LUCY for computer assisted structure elucidation. In 1996, he joined the group of Prof. Clemens Richert at Tufts University in Boston, MA, USA, where he worked in the area of biomolecular NMR on the 3D structure elucidation of peptide-nucleic acid conjugates. In 1997 Christoph Steinbeck became head of the Structural Chemo- and Bioinformatics Workgroup at the newly founded Max-Planck-Institute of Chemical Ecology in Jena, Germany. In fall 2002 he moved to Cologne University Bioinformatics Center (CUBIC) as head of the Research Group for Molecular Informatics. His research focuses on methods for Computer-Assisted Structure Elucidation in Metabolomics and Natural Products Research. In December 2003 Christoph Steinbeck received his Habilitation in Organic Chemistry from Friedrich-Schiller-University in Jena, Germany.
His group develops a number of the leading open source software packages in Chemo- and Bioinformatics, including the Chemistry Development Kit (CDK), a Java library for chemo- and bioinformatics, NMRShiftDB, an open content database for chemical structures and their NMR data, and Bioclipse, an Eclipse-based Rich Client for everything and nothing in particular. Dr. Steinbeck is chairman of the Computers-Information-Chemistry (CIC) division of the German Chemical Society, trustee of the Chemical Structure Association (CSA) Trust, a lifetime member of the World Association of Theoretically Oriented Chemists (WATOC) and member of various editorial boards and committees. Today, Dr. Steinbeck is a lecturer in Chemoinformatics at the University of Tübingen, an Evangelist for Open Data, Open Standards and Open Source, and works as an independent consultant in Chemo- and Bioinformatics.
Education
10/01–08/05: |
Bioinformatics modules, University of Manchester, |
09/97–10/98: |
MSc Computing Science, University of Newcastle-upon-Tyne. |
09/92–06/96: |
BSc (Hons) Chemistry with Industrial Experience, University of Manchester. First class honours. Industrial experience with Dow Deutschland Inc. |
Cancer Research Campaign (01–05/96) Paterson Institute of Cancer Research, Christie Hospital, Manchester. BSc thesis: physical organic chemistry. |
Employment
04/06– present: |
Manchester Centre for Integrative Systems Biology, University of Manchester, Manchester, Experimental Officer (Information Management). |
04/99–04/06: |
Waters Corporation, Micromass MS Technologies Centre, Manchester, Bioinformatics Team Manager. |
10/98–03/99: |
AstraZeneca, Formally at: Hexagon House, Blackley, Manchester. Graduate trainee: IT problem management. |
12/96–08/97: |
The British Council, Bridgewater House, Manchester. Website editorial assistant. |
09/94–09/95: |
Dow Deutschland Inc. Werk Stade, Postfach 1120, 21677 Stade, Germany. |
Degrees etc.
B.Sc. (Biochemistry), St Andrews University (1962); M.A. (1965), Ph.D. (1966); Cambridge University; M.R.I.A. (1984)
Main Posts:
University of Cambridge: Demonstrator & Lecturer (1965–1977). Fellow of King's College Cambridge (1965–1977).
University of Dublin: Professor of Biochemistry (1997– present).
Fellow of Trinity College, Dublin (1979- present).
Visiting Professor: Universities of Florence (1976, 1993 & 2003) & Siena (1987 & 1999); Autonomous University of Barcelona (1988–89).
Publications:
Over 250 papers in refereed journals; 35 papers as chapters in books; editor of 19 books, >150 abstracts; 1 patent, co-author of three books.
Research Interests:
Enzymology: regulation, kinetics, inhibition, isolation, applications and classification. Metabolic analysis and simulation. Neurochemistry: depression, degenerative diseases and ‘neuroprotection’. Biochemical Pharmacology: drug design, ethanol.
is a research associate in the Scientific Database and Visualisation group of the EML Research gGmbH in Heidelberg, Germany. She studied biochemistry at the University of Leipzig, Germany and received her Ph.D. in biology from the University of Heidelberg, Germany in 1998. The Ph.D. thesis on mechanisms of apoptosis and oxidative stress was developed in a close collaboration between the University Hospital of Heidelberg and the German Cancer Research Center in Heidelberg. With the background of wet-lab work she joined a new founded group for Bioinformatics at the European Media Laboratory (EML) in Heidelberg and worked at the development of databases for biochemical pathways. Her research interests include modelling and visualisation of biochemical pathways, information extraction from biological data sources and data integration and standardisation in biological databases.
Published in: "Experimental Standard Conditions of Enzyme Characterizations", Martin G. Hicks & Carsten Kettner (Eds.),
Proceedings of the Beilstein-Institut Workshop, September 23rd – 26th, 2007, Rüdesheim, Germany.
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