Overview

 

Time-resolved measurements of the molecular activities of enzymes during catalysis correlate the conformational and chemical events that occur during the catalytic cycle.  Beyond catalysis of isolated enzymes, such measurements are used to elucidate the coordinated interactions of proteins with larger macromolecules and assemblages, which often require precise spatiotemporal positioning of the partners within the greater context of the cell to faithfully execute higher order cellular functions. Gene expression is often triggered in response to extra- or intracellular stimuli, such as light, gravity, nutrients, toxins, hormones, etc. Enzymes and other signal‑cascade proteins capture and transduce these diverse signals into discrete chemical entities that inform and direct cellular behaviour. Molecular-information processing networks require the coordinated interplay of numerous components, and are the focus of systems-biological investigations aimed at understanding, for example, the spread of disease, or identifying targets that can control signal-transduction.

The Beilstein Enzymology Symposia embrace structural, computational and biological disciplines, and bring researchers (established and younger workers) together to discuss the many and diverse roles of enzymes in biology, and to explore the limits and challenges of holistic studies that attempt to integrate microscopic views of protein function into complex biological behaviour. Under the guidance of the STRENDA Commission, this conference series also provides a platform to discuss current standards in biochemistry.  The mission of STRENDA is to establish guidelines for the reliable and accurate reporting of protein function data, and to create a database (STRENDA DB) to capture and disseminate this data as it enters the literature. All participants are encouraged to discuss their latest results, approaches and methodologies in experimental, theoretic and bioinformatics enzymology.