Thanks to the technological developments in recent years in the areas of control devices, flow reactors and miniaturization of reaction vessels, syntheses can be automated to a large extent. In addition to the automation, new approaches to carry out the reactions are developed and tested.
Numerous publications of the Beilstein-Institut have illustrated some of the new synthetic techniques. You will find here examples of articles and videos.
Use of a Raspberry Pi computer
Steve Ley and his group at Cambridge University uses a Raspberry Pi computer for automated synthesis. The Raspberry Pi machines are of very simple design and were originally developed to offer students a low-cost platform for learning a programming language.
Reaction monotoring with digital cameras
The same group also uses digital cameras for reaction control. By means of intelligent image recognition, a highly automated control of chemical reactions can be performed.
Mikroreactors from the 3D printer
Leroy Cronin, Philip Kitson, Mark Symes and Ross Forgan use 3D printers for the production of microreactors. This allows very fast and inexpensive optimization of flow reactors for certain reactions.
Photochemistry in flow
In this review article, Kevin Booker-Milburn,from Bristol University describe how UV light can be combined with flow reactors.
A total of 64 research articles are included in the three Thematic Series "Chemistry in flow systems", which were edited by Andreas Kirschning, professor at the Leibniz Universität Hannover, in the Beilstein Journal of Organic Chemistry.