Contents

Impressum
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Preface
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Ley, S.V., Baxendale, I.R. and Myers, R.M.
Evolution or Revolution: The Challenge to Today's Medicinal Chemist
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Russell, K. and Michne, W.F.
The Value of Chemical Genetics in Drug Discovery
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Kubinyi, H.
Changing Paradigms in Drug Discovery
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Freire, E.
Thermodynamics in Drug Design. High Affinity and Selectivity
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Micklefield, J. and Smith, C.P.
Engineering the Biosynthesis of Nonribosomal Lipopeptide Antibiotics
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Cornish, V.W., Lin, H., Baker, K., Salazar-Jimenez, G.J., Abida, W., Bleckzinsky, C., Sengupta, D., Krane, S. and Tao, H.
Chemical Complementation: A Reaction-Independent Genetic Assay for Directed Evolution
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Hert, J., Willett, P. and Wilton, D.J.
Virtual Screening Using Binary Kernel Discrimination
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Bleicher, K.H., Alanine, A.I., Roger-Evans, M. and Schneider, G.
GPCR Hit Discovery Beyond HTS
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Patterson, S., Lucas-Lopez, C. and Westwood, N.J.
Selective Chemical Intervention in Biological Systems: The Small Molecule Tool, (S)-(-)-Blebbistatin
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Gasteiger, J., Reitz, M. and Sacher, O.
Multidimensional Exploration into Biochemical Pathways
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Cornish-Bowden, A. and Cárdenas, M.L.
Handling Equilibrium Processes Embedded in Metabolic Systems
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Schneider, G., Renner, S. and Fechner, U.
Navigation in Chemical Space Based on Correlation-Vector Representation of Molecules
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Goldstein, R.A.
Evolutionary Perspectives on Protein Stability
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MacDonald, A.J., Parrott, N., Jones, H. and Lavé, T.
Modelling and Simulation of Pharmacokinetic and Pharmacodynamic Systems - Approaches in Drug Discovery
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Davies, K.
The Final Curtain
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Biographies
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